It's the same old Spider-Man start up film. High school kid Peter Parker (played by 28 year old Andrew Garfield) gets bitten by spider (and so develops spider skills). He indirectly causes the death of his uncle (Martin Sheen), fights a baddie (Rhys Ifans) who thinks people should be made to involve into lizards (apparently they're a higher life form despite their cold bloodedness), doesn't meet Mary Jane (no idea why), but meets someone else instead (as love interest (played by the 23 year old Emma Stone).
It's not exactly The Magnificent Ambersons, but it's not bad as a film either. It's slightly darker than the Sam Raimi/Tobey MaGuire films, but I think that worked better for the film (and the time we live in). The darkness answers the question what normal kid says "hey I've got the skills of a spider, now I'm gonna chase baddies."